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Southern Research Institute provides medicinal chemistry and database expertise in Birmingham, AL and Frederick, MD. SRI's team of the TAACF, led by Dr. Jack Secrist, interacts with interested compound suppliers and coordinates all compound acquisition duties, data entry and database maintenance, testing coordination, and data report generation and delivery.

SRI Process Flow Chart: Candidate Compound Identification and Acquisition Services and High-Throughput Screening Services

Follow the flow chart to learn more about the procedures for submitting compounds to be screened. Upon receipt of compounds, TAACF medicinal chemists review compound information and determine the appropriate in vitro screening assays to use. Compounds may be evaluated via SRI's high-throughput screening (HTS) assays.

Blue text links are provided to downloadable documents or detailed descriptions of that step of the procedure.

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Supplier fills out two copies of the Material Evaluation Agreement and sends them to TAACF
Link to Material Evaluation Agreement.
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Link to TAACF
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Supplier receives agreement; consults with TAACF medicinal chemist; submits compounds list
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Medicinal chemists review structures and recommend compounds for submission If compounds are not recommended: no further evaluation
If compounds are recommended: SRI notifies supplier
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Supplier sends approved compounds with physical data with the compound submission formText description of this process
Link to compound submission form
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SRI acknowledges receipt and schedules in vitro testing
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  in vitro testing is done at SRI's high throughput screening center  
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Arrow down to decision diamondLink to SRI's High Throughput Screening


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