Current TB Drugs
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Isoniazid (INH), 1952
MIC=0.025-0.2 µg/mL
Target: Long Chain ACP-Enoyl Fatty Acid Reductase
Toxicity: Hepatic
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Rifampin (RMP), 1957
MIC = 0.06-0.5 µg/mL
Target: RNA Polymerase
Toxicity: Hepatic
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Ethambutol (EMB), 1962
MIC = 0.95-7.5 µg/mL
Target: Synthesis of Arabinose, Arabinomannan and Lipoarabinomannan
Toxicity: Ocular
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Pyrazinamide (PZA), 1952
MIC = 6-60 µg/mL
Target: Unknown
Toxicity: Hepatic
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Rifapentine
Target: RNA Polymerase
Toxicity: Hepatic |
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p-aminosalicylic acid (PAS), 1946
MIC = 1-10 µg/mL
Target: Folate Synthesis? Iron Transport?
Toxicity: GI, Hypersensitivity
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Cycloserine, 1952
MIC = 6-25 µg/mL
Target: Dipeptide Synthetase and Alanine Racemase
Toxicity: CNS |
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Ethionamide (ETA), 1956
MIC = 0.3-10 µg/mL
Target: Long Chain ACP-Enoyl Fatty Acid Reductase
Toxicity: Hepatic
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Streptomycin, 1943
MIC = 0.25-2 µg/mL
Target: 30S Ribosomal Subunit
Toxicity: 8th Cranial Nerve
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