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General Submission Information

In order to begin participating in the TAACF program a potential supplier need only complete a Screening Agreement and send the signed agreement along with a list of potential screening candidates.  The Supplier Agreement is a legal document between NIH, all contracted institutions, and the supplier. The document protects the supplier from violations of confidentiality.

Along with the compounds, certain information must also be provided. The required information includes, but is not limited to, the following:

  • chemical structure
  • solubility
  • name
  • chemist's compound ID code
  • molecular formula
  • molecular weight

To facilitate the transmission of data, all information may be transferred to the TAACF electronically, either on diskette or by e-mail attachment. If mail correspondance is necessary, compound information may be mailed along with the samples using a TAACF data sheet (see below). 

Compounds are screened on a first come-first served basis. Browse to a description of the assays used to screen the candidate compounds.

Official Submission Procedures

  1. Two copies of the Screening Agreement should be properly executed by an appropriate official of the Supplier’s organization and returned to the TAACF. The TAACF will then arrange for signature by an NIAID official and return one fully signed copy to the Supplier.
  2. Supplier should select compounds for screening in consultation with TAACF medicinal chemists, and should submit a confidential list of compound structures, preferably in electronic format. If appropriate, a visit with a TAACF medicinal chemist can be scheduled to discuss compound selection. The structures should be submitted by mail to:

TAACF

Southern Research Institute

PO Box 55305

Birmingham, AL 35255-5305

3.TAACF medicinal chemists will ensure that candidate compounds are appropriate for screening and have not been previously submitted, and will then recommend to Supplier compounds for submission.

4.Supplier should submit samples of each compound to be screened in vials, preferably of 1 dram size with screw caps; vials will be provided to Supplier, if requested.  Supplier should reference the Assay Page for specific sample quantity requirements. Vials should be clearly labeled with a Supplier identification number or code, and appropriate physical data should be submitted for each compound. Use a printed version of our datasheet if desired.  Please note that if providing < 3 mg, it is necessary to provide exact sample weights on the vial, since such samples will not be re-weighed prior to screening. Compounds and data sheets or diskettes should be shipped by express courier to:

 

TAACF – FRC

Attention: Mr. Adrian Poffenberger

Southern Research Institute - Frederick

431 Aviation Way

Frederick, MD 21701-4756

Help in compound submission (e.g., assistance in weighing/packaging samples, shipping expenses) may be available upon request.

 

5.TAACF chemists will acknowledge receipt of compounds, schedule them for testing, and report data to Supplier as received from the screening facility.