Current TB Drugs
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Isoniazid (INH), 1952 MIC=0.025-0.2 mg/mL Target: Long Chain ACP-Enoyl Fatty Acid Reductase Toxicity: Hepatic | Ethionamide (ETA), 1956 MIC = 0.3-10 mg/mL Target: Long Chain ACP-Enoyl Fatty Acid Reductase Toxicity: Hepatic | |
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| p-aminosalicylic acid (PAS), 1946 MIC = 1-10 mg/mL Target: Folate Synthesis? Iron Transport? Toxicity: GI, Hypersensitivity | Pyrazinamide (PZA), 1952 MIC = 6-60 mg/mL Target: Unknown Toxicity: Hepatic | |
| Cycloserine, 1952 MIC = 6-25 mg/mL Target: Dipeptide Synthetase and Alanine Racemase Toxicity: CNS | Ethambutol (EMB), 1962 MIC = 0.95-7.5 mg/mL Target: Synthesis of Arabinose, Arabinomannan and Lipoarabinomannan Toxicity: Ocular | |
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Rifampin (RMP), 1957 MIC = 0.06-0.5 mg/mL Target: RNA Polymerase Toxicity: Hepatic | Streptomycin, 1943 MIC = 0.25-2 mg/mL Target: 30S Ribosomal Subunit Toxicity: 8th Cranial Nerve | |
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| Rifapentine Target: RNA Polymerase Toxicity: Hepatic |
